Potentiation: Neurology and Knowledge Management

There is a wonderful term that cognitive neurologists use, “potentiation.” It’s a term that those of us that are involved in knowledge and learning could make great use of – no need for neurologist to have all the fun!

Here is what it means to a cognitive neurologist, as translated by an amateur with a few graduate courses in neurology. Information moves along neurons and when the information reaches an axon terminal, in order to go any further it has to jump the synaptic gap to the next neuron. It jumps the gap by producing a neurotransmitter that the next neuron picks up (neurologists say the neurotransmitter excites the next neuron) and off the information goes down the next neuron (and the next) until it gets to some important destination where the message tells your little finger to wiggle or you arrive at a brilliant new insight. Of course, it’s all a good deal more complex since that lone neuron is also exciting lots of other neurons and even turning some off – but for the purpose of thinking about how it impacts knowledge, lets stay simple.

Now it turns out that each time the neurotransmitter excites its neighboring neuron that pathway becomes stronger and can be more easily excited the next time. An example of a path that is very weak is that uncomfortable experience of meeting someone and ten minutes later not being able to remember her name. Each time the pathway is excited it becomes more potentiated, that is, more accessible the next time. Building the strength of synaptic communication is the neurological basis for learning.

Now here is the interesting part. The synaptic gap is excited, once, twice, three times, each time sending out one type of neurotransmitter. But if you really excite that next neuron over and over finally it releases a different kind of neurotransmitter, (one with a calcium base) and that type of neutrotransmiter has a hundred times more capability to excite the next neuron and produces Long Term Potentiation (LTP). It is not a linear progression- it is exponential. So an idea keeps exciting the next neuron gradually getting a little stronger each time, then there is a sudden burst and wham! the idea is now firmly fixed in your mind - LTP. Having achieved LTP the idea is easily brought to mind, the slightest hint or related idea will bring it to the fore. That makes it incredibly available for immediate use, like the expert chess players who with only a glance at the board can see potential patterns that might emerge during the game. Learning is not linear – it is exponential!

The first time we hear a very new idea serves as a kind of preparation for later understanding that idea; the connection is weak, but it’s there – potentiation has occurred. You may not even know its there but it is. Then we hear the idea again, a week or a month later and the connection gets a little stronger – it still may not be strong enough for you to recall the idea. But you might at least have recognition the next time you hear it as in, “Oh, yes, I do remember now that you mention that.”

I had that experience about three years ago when I was at a meeting where Bill Ives was speaking about Web 2.0. Now Bill is a guru of social media, so even back then he was talking about the value of blogs, wikis and rss feeds. I liked what he said and was intrigued about the idea of Web 2.0 – but by the time the meeting, and several other speakers, was over, my thinking about blogs was over as well. The idea was potentiated but not strong enough for me to give it much thought in the subsequent weeks and months.

But probably like you, over the next three years I kept hearing about blogs, in articles and presentations. Last month Dave Snowden and I were both speaking at KM Asia and Dave talked about blogs and the value they bring to his own learning and the idea went LTP! And I started blogging. Now, I don’t think it’s that Dave is a more convincing speaker than Bill, to the contrary, if I hadn’t heard Bill’s speech three years ago I don’t think Dave’s speech would have been able to trigger me to start writing a blog.

There are a number of implications that come to mind for me, two that explain some of difficulties people face, and several that have more positive aspects. The negative ones first-

• LTP explains how people can get an idea so firmly fixed in their minds – a connection that has long term potentiation - that it seems that no amount of new evidence will impact their thinking. For example, someone who bought a Toyota in 1975, that turned out to be a lemon, and will never buy another Toyota no mater what consumer reports says about its reliability in 2009.




• LTP also explains Post Traumatic Stress Syndrome, when even the smallest reminder of a traumatic stress will trigger it again – so sensitized is the connection between those neurons.

But on the more positive side:

• Learning theorists know about potentiation – they call it “foreshadowing.” They advise teachers to introduce a concept before it comes up in the curriculum or lecture. Foreshadowing prepares the mind of the listener or the reader for an idea to come. In the vernacular it’s the familiar, “Tell ‘em what your going to tell ‘em; tell ‘em; then tell ‘em what you told ‘em. Not a bad way to strengthen potentiation any time we are introducing a new idea.




• I explain to a colleague just why it’s imperative that he support the redesign of the development process and I can tell he’s listening but I can also tell he isn’t getting it. I could walk away from that exchange thinking that he is just not a forward thinking individual, or any of a hundred other attributions we make about those that don’t immediately take to our ideas. Or I can assume, “it is early days;” I can say to myself, “He doesn’t get it yet but I have started the potentiation process.




• There is a great story about Rosa Parks that illustrates potentiation for all of us who facilitate workshops. Rosa Parks attended a workshop on school desegregation at Highlander in 1955. At the end of the workshop the Highlander staff asked, as we often do at the end of a workshop, "What are you going to do when you go back?" Many of the participants said, probably not much because they didn’t think the black community would stick together to fight segregation. Rosa’s response was, "Montgomery is the cradle of the confederacy. The white people won't let black people do anything." And she echoed the sentiment of the others, "Even if they did, I don't know whether we'd stick together or not." Then a few weeks later in Montgomery Rosa Parks refused to give up her seat on the bus to a white man, triggering the Montgomery boycott that drew national attention to the civil-rights movement. At the end of their workshop the facilitators at Highlander must have felt a disappointment at the response to their question. Apparently they had changed few, if any, minds. Yet, there was potentiation occurring in that room. You wonder how many times those synaptic connections had to be strengthened for the Montgomery bus boycott to occur.

David Bohm, the great physicist and one of my heroes said, “When you listen to somebody else, whether you like it or not, what they say becomes part of you.”

Comments

[Matt Moore]

I believe that persistence is key attribute of anyone engaged in knowledge management or organisational learning. It can take years.

Another metaphor that often comes to mind is surfing. You sit on your board in the swell and nothing happens to the longest time. You talk to people. You try a few things.

And then, somewhere just in front of you, an enormous wave rises out the ocean and you are directly in its path.

All you've been doing is talking. And trying a few things. And all you can do now is try to ride this force that is not you.

I think more knowledge managers should surf. May be they'll add it to the certification courses.

Keep on bloggin'.

[Jim Galvin]

Nancy - thanks for sharing the potentiation concept. It's very powerful. We often talk about "planting seeds." I suspect there's a connection from potentiation to marketing, branding and strategic communications. Rather than trying to high torque an audience all at once, a deliberate, systemic drumbeat may be more effective.

[Nancy Dixon]

Jim,
I like your drum beat analogy. For me potentiation is a very hopeful concept that says people change, not linearly and certainly not alway when we would like, but the possibility of change is always there.
Nancy

[neurodojo.blogspot.com]

Please forgive me if I make some corrections. Sorry, but I'm a neurobiologist, and I'm handicapped by my blind obsession with factual details. ;)

"The synaptic gap is excited, once, twice, three times, each time sending out one type of neurotransmitter. But if you really excite that next neuron over and over finally it releases a different kind of neurotransmitter..."

The presynaptic neuron does not change the neurotransmitter it releases during LTP. It continues releasing the SAME neurotransmitter, which is glutamate.

The postsynaptic neuron, however, has two different RECEPTORS for glutamate. One type, AMPA receptors, open when the postsynaptic neuron is weakly stimulation (depolarized). The second type, NMDA receptors, open when the neuron is strongly stimulated.

Yes, I know the name of the receptors are confusing. You would think an "NMDA receptor" would normally be looking for an NMDA molecule rather than a glutamate molecule. The receptor types are named for molecules that mimic the effects of glutamate.

The relationship between LTP and learning is complicated. LTP was discovered in 1973, but there weren't clear demonstrations it was involved in learning until about 2006. And there are some regions of the brain that show LTP, but use completely different mechanisms than described here; no NMDA receptors are involved.

It's a VERY long reach to say, "LTP explains how people get ideas fixed in their minds." In studies in the lab, LTP can lasts for hours, or days, sometimes weeks, but it isn't necessarily permanent. Plus, there is not only LTP, but LTD (long term depression -- not depression = sad, but depression = less postsynaptic response), too. Nervous systems have to be forget as well as remember.